This review aims to evaluate recent literature and guidelines regarding CVD in T1D.Recent findings: At the cellular level, the early stage of CVD is characterised by endothelial dysfunction. While the association of type 2 diabetes (T2D) with cardiovascular disease has been well described, the mechanisms, risk stratification and screening strategies of CVD in type 1 diabetes (T1D) are less understood. ![]() N2 - Purpose of Review: Cardiovascular disease (CVD) is a well-recognised complication of diabetes. T1 - Cardiovascular Disease in Type 1 Diabetes Routine screening of coronary artery disease does not alter outcomes and is therefore not recommended however, risk prediction tools are being developed to aid identification of high risk individuals for aggressive risk factor modification strategies.", Coronary artery disease (CAD) is the most significant contributor to CVD and in T1D, has a propensity towards a more silent and severe form. This is driven by hyperglycaemia-mediated oxidative stress and vascular inflammation, resulting in atherosclerosis and cardiac autonomic neuropathy. The latest version (QRISK3) is likely to be recommended for routine use in T1D patients in upcoming guidelines by the National Institute of Clinical Excellence (NICE).Summary: Mortality in adults with T1D is increasingly due to CVD. ![]() The latter risk prediction tool is used for all patients but contains T1D as an independent risk variable and has the advantage of being derived from, and validated in, a large and diverse population. Foremost amongst these are the Danish Steno Type 1 risk engine, the Swedish T1D risk score, the Scottish T1D risk score and the QRISK risk calculator. Recent studies have shown that endothelial function is unaffected in younger T1D patients but there is a significant degree of endothelial dysfunction in the older T1D population compared to healthy age-matched controls, highlighting the importance of the endothelial dysfunction in T1D as a major age-dependent cardiovascular risk factor.T1D risk assessment tools have been developed similar to those seen in T2D. Routine screening of coronary artery disease does not alter outcomes and is therefore not recommended however, risk prediction tools are being developed to aid identification of high risk individuals for aggressive risk factor modification strategies.Ībstract = "Purpose of Review: Cardiovascular disease (CVD) is a well-recognised complication of diabetes. Summary: Mortality in adults with T1D is increasingly due to CVD. The latest version (QRISK3) is likely to be recommended for routine use in T1D patients in upcoming guidelines by the National Institute of Clinical Excellence (NICE). ![]() ![]() T1D risk assessment tools have been developed similar to those seen in T2D. Recent studies have shown that endothelial function is unaffected in younger T1D patients but there is a significant degree of endothelial dysfunction in the older T1D population compared to healthy age-matched controls, highlighting the importance of the endothelial dysfunction in T1D as a major age-dependent cardiovascular risk factor. Recent findings: At the cellular level, the early stage of CVD is characterised by endothelial dysfunction. This review aims to evaluate recent literature and guidelines regarding CVD in T1D. Purpose of Review: Cardiovascular disease (CVD) is a well-recognised complication of diabetes.
0 Comments
Leave a Reply. |